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[Cutaneous Rosai-Dorfman disease]
Yun-yi Kong1, Hong-fen Lu, Xiong-zeng Zhu
1Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China. kyydb@yahoo.com.cn
Summary
Cutaneous Rosai-Dorfman disease (CRDD) presents as skin lesions without systemic involvement. Diagnosis relies on identifying S-100 positive histiocytes with emperipolesis, distinguishing it from other histiocytic disorders.
Area of Science:
- Dermatopathology
- Histiocytic Disorders
- Immunohistochemistry
Context:
- Cutaneous Rosai-Dorfman disease (CRDD) is a rare, benign histiocytic proliferation.
- Understanding its clinicopathologic features is crucial for accurate diagnosis and management.
Purpose:
- To elucidate the clinicopathologic features, immunophenotype, and differential diagnosis of CRDD.
- To provide diagnostic criteria for CRDD based on histological and immunohistochemical findings.
Summary:
- Eight cases of CRDD exhibited multiple cutaneous papules/nodules on extremities or trunk without systemic symptoms.
- Histopathology revealed S-100 positive histiocytes with emperipolesis, mixed inflammatory infiltrate, and stromal changes in chronic cases.
- Immunohistochemistry for S-100 and CD68 aids in differentiating CRDD from other histiocytic and lymphoproliferative disorders.
Impact:
- Establishes key diagnostic markers for CRDD, improving diagnostic accuracy.
- Highlights the typically benign and self-limiting nature of cutaneous forms.
- Guides clinicians in differentiating CRDD from potentially malignant or systemic conditions.