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[Extranodal Rosai-Dorfman disease]
Mei-fu Gan1, Tao Zhou, Xin-ru Yu
1Department of pathology, Taizhou Hospital of Zhejiang Province, Linhai 317000, China. gmeifu@sohu.com
Summary
Extranodal Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder. Diagnosis requires identifying characteristic large histiocytes with emperipolesis and distinguishing it from other fibrohistiocytic lesions.
Area of Science:
- Histopathology
- Oncology
- Immunology
Context:
- Extranodal Rosai-Dorfman disease (RDD) is a rare, idiopathic proliferative disorder of histiocytes.
- It presents with distinct morphologic features, posing diagnostic challenges.
Purpose:
- To investigate the diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease.
- To highlight key histopathological features for accurate identification.
Summary:
- Two cases of extranodal RDD were analyzed using hematoxylin-eosin and immunohistochemical staining.
- Key findings include large histiocytes with emperipolesis, positive S-100 staining, and infiltration by inflammatory cells.
Impact:
- This study aids in differentiating extranodal RDD from other fibrohistiocytic lesions.
- Accurate diagnosis is crucial for appropriate patient management.