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Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Synovial biopsy.

Danielle Gerlag¹, Paul P Tak

¹Division of Clinical Immunology and Rheumatology, F4-218, Academic Medical Centre, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.

Best Practice & Research. Clinical Rheumatology

|June 9, 2005

Summary

Synovial tissue biopsy is a safe and effective method for analyzing arthritis. This technique aids in understanding disease mechanisms and treatment responses, with potential diagnostic value in specific cases.

Area of Science:

Rheumatology
Orthopedics
Pathology

Background:

Synovial tissue is readily accessible in arthritis patients.
Arthritis research benefits from accessible tissue analysis.

Purpose of the Study:

To highlight the utility of synovial tissue biopsy in arthritis.
To discuss its role in understanding disease mechanisms and treatment response.
To explore its potential diagnostic applications.

Main Methods:

Blind needle biopsy: a simple and safe procedure.
Arthroscopic biopsy: safe, versatile, and yields adequate tissue for extensive analysis.
Tissue analysis before and after therapy.

Main Results:

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Synovial Fluid Analysis to Identify Osteoarthritis

Synovial Fluid Analysis to Identify Osteoarthritis

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Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

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Last Updated: Mar 16, 2026

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Synovial Fluid Analysis to Identify Osteoarthritis

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

Synovial tissue analysis effectively elucidates disease mechanisms.

It accurately assesses patient response to therapeutic interventions.

Biopsy provides ample tissue for comprehensive laboratory investigations.

Conclusions:

Synovial tissue biopsy is a valuable tool in arthritis research and patient management.
Both blind needle and arthroscopic biopsy methods are safe and informative.
Diagnostic synovial biopsy is indicated in select arthritis cases.