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Coronary artery calcification and risk factors for atherosclerosis in patients with venous thromboembolism

Cheng Hong1, Fang Zhu, Duanming Du

  • 1Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8131, 510 S Kingshighway Blvd., St. Louis, MO 63110, USA.

Atherosclerosis
|June 9, 2005
PubMed

Insights

Coronary atherosclerotic disease (CAD) is linked to venous thromboembolism (VTE). This study found CAD, diabetes, and hypertension are independent risk factors for VTE, highlighting shared pathways.

Area of Science:

  • Cardiovascular Medicine
  • Hematology

Background:

  • Venous thromboembolism (VTE) and atherosclerosis share potential risk factors.
  • Investigating the association between VTE and coronary atherosclerotic disease (CAD) is crucial.

Purpose of the Study:

  • To examine the relationship between VTE and CAD.
  • To assess coronary artery calcification and clinical risk factors in VTE patients.

Main Methods:

  • Retrospective case-control study of 178 patients (89 VTE cases, 89 controls).
  • Coronary artery calcification quantified using CT angiography.
  • Logistic regression analysis used to assess associations.

Main Results:

  • Higher coronary artery calcium prevalence in VTE cases (51.7%) vs. controls (28.1%).
  • Coronary artery calcium significantly associated with VTE (OR 4.3).
  • Diabetes mellitus and hypertension independently associated with VTE.

Conclusions:

  • Coronary atherosclerotic disease is an independent risk factor for VTE.
  • Diabetes and hypertension are also independent risk factors for VTE.
  • Shared risk factors suggest common pathophysiological mechanisms.
Abstract

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