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Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.
Molecular Psychiatry
|June 9, 2005
Summary
The TPH2 gene, involved in serotonin production, shows a significant association with attention-deficit hyperactivity disorder (ADHD). This suggests TPH2 may be a genetic susceptibility factor for ADHD, particularly through paternal transmission.
Area of Science:
- Neurogenetics
- Psychiatric Genetics
Background:
- Serotonin (5-hydroxytryptamine, 5-HT) is implicated in attention-deficit hyperactivity disorder (ADHD) etiology.
- Tryptophan hydroxylase (TPH) synthesizes serotonin; TPH2 is the brain-specific form.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in the TPH2 gene and ADHD.
- To explore TPH2 as a potential susceptibility locus for ADHD.
Main Methods:
- Examined eight SNPs in the TPH2 gene within 179 Irish nuclear families.
- Utilized Transmission Disequilibrium Test (TDT) analysis.
- Conducted haplotype analysis and stratified analysis by parental transmission sex.
Main Results:
- Significant association found between the T allele of TPH2 marker rs1843809 and ADHD (P=0.0006).
- Association was stronger with paternal transmission (OR=3.7).
- Several TPH2 haplotypes, including rs1843809, were associated with ADHD.
Conclusions:
- Preliminary evidence suggests TPH2 is a susceptibility locus for ADHD.
- TPH2 may play a role in the pathophysiology of ADHD.
- Further research in diverse ethnic groups is needed for confirmation.