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Rapidly destructive Staphylococcus epidermidis endocarditis.

A S Zinkernagel1, R F Speck, C Ruef

  • 1Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistr. 100, 8091 Zurich, Switzerland. annelies.zinkernagel@usz.ch

Infection
|June 9, 2005
PubMed
Summary
This summary is machine-generated.

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Staphylococcus epidermidis can rapidly destroy heart valves, leading to treatment failure. Successful management of this severe endocarditis requires a combination of valve replacement surgery and targeted antibiotic therapy.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Antimicrobial Resistance

Background:

  • Staphylococcus epidermidis is a common cause of prosthetic device infections, including endocarditis.
  • Mitral valve reconstruction surgery carries a risk of developing infective endocarditis.

Observation:

  • A case of rapidly destructive Staphylococcus epidermidis endocarditis in a 29-year-old male post-mitral valve reconstruction is presented.
  • The patient developed resistance to rifampin and teicoplanin during initial antibiotic treatment, leading to clinical failure and significant valve destruction.

Findings:

  • The patient ultimately required valve replacement surgery.
  • Successful treatment was achieved with a combination of quinupristin/dalfopristin, levofloxacin, and vancomycin post-surgery.

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Implications:

  • Staphylococcus epidermidis can cause aggressive valve destruction and present with large vegetations.
  • Multidrug-resistant S. epidermidis endocarditis may necessitate a combined surgical and antibiotic approach for effective management.