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Updated: Aug 1, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Linezolid contributed to Clostridium difficile colitis with fatal outcome
1Institut für Laboratoriumsmedizin, Klinik am Eichert, Eichertstr. 3, 73035 Göppingen, Germany. Lutz.Zabel@kae.de
Abstract:
Linezolid, the first of a new class of antibacterial drugs, the oxazolidinones, has inhibitory activity against a broad range of gram-positive aerobic cocci and also against certain anaerobes. Although diarrhea is one of the most frequently encountered adverse effects of linezolid, Clostridium difficile-related complications are very uncommon. One case of fatal C. difficile colitis in a patient with spondylodiscitis, who had received a long-term course of linezolid therapy, is presented. Colitis was able to be exclusively assigned to linezolid. Factors contributing to the colitis are discussed.
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