Freiberg's infraction in identical twins: a case report

Area of Science:

• Orthopedics and Sports Medicine
• Genetics and Molecular Biology

Background:

• Freiberg's infraction is a degenerative condition affecting the metatarsophalangeal joint, commonly linked to repetitive microtrauma.
• Etiologic theories include trauma, aseptic necrosis, ischemia, and congenital predisposition.

Observation:

• A rare case of Freiberg's infraction in identical twins is presented.
• The condition affected multiple metatarsals in varying stages of degeneration.
• One twin exhibited unilateral involvement, while the other had bilateral presentation, with both showing involvement of the second metatarsal.

Findings:

• The occurrence in identical twins suggests a significant genetic component in Freiberg's infraction.
• This case challenges the predominant theory of repetitive microtrauma as the sole cause.

Implications:

• Highlights the potential role of genetic predisposition in the pathogenesis of Freiberg's infraction.
• Suggests further research into genetic factors and their interaction with biomechanical influences.
• May inform future diagnostic and therapeutic strategies for this condition.