[Expression of P53 and Bax in rat liver induced by microcystin LR in vivo]
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Published on: March 28, 2018
Xiu-min Wang1, Jia-ping Chen, Wen-yu Fu
1Department of Biochemistry and Molecular Biology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Objective:
To examine the expression of P53, Bcl-2 and Bax proteins in rat liver after exposed to microcystin LR.
Methods:
SD rats received microsystin LR by gastric perfusion. The expression of P53, Bax and Bcl-2 in liver was detected by Western blot.
Results:
The expression of P53 and Bax in each treatment group increased significantly compared with that in control group(P<0.05), with the exception of 0.1 microg/kg LR exposure group. Moreover, with exposure levels increasing the expression of P53 and Bax increased gradually; while no changes of the expression of Bcl-2 were observed.
Conclusion:
P53 and Bax may play important roles in microcystin LR induced apoptosis, but Bcl-2 seems not be involved in this process.
