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Are SSRIs really more effective for anxious depression?
1Fox Valley Psychiatric Associates, Appleton, WI 54915, USA. EPanzer@new.rr.com
Background:
Selective Serotonin Reuptake Inhibitors (SSRIs) are well-established first-line agents for Anxiety Disorders. Anxiety is also a frequent manifestation of major depression. Many psychiatrists assume that anxious depression is more responsive to SSRIs than to other antidepressants. The purpose of this literature review was to determine if SSRIs or any other antidepressants are superior.
Methods:
A computerized search was conducted of double-blind, English-language studies comparing antidepressants available in the United States. Databases searched included Medline and PsycINFO.
Results:
SSRIs were not found to be superior to other antidepressants in the treatment of anxious depression.
Conclusions:
The above assumption is not supported. Treatment implications are discussed.
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Antidepressant Drugs: Overview
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Antidepressant Drugs: MAOIs and Other Agents
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Anxiolytic Drugs: Benzodiazepines and Buspirone
Drug Therapy
Antianxiety Medications

