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Novel anhydrous emulsions: formulation as controlled release vehicles
Orawan Suitthimeathegorn1, Vikas Jaitely, Alexander T Florence
1Centre for Drug Delivery Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
International Journal of Pharmaceutics
|June 9, 2005
Summary
New anhydrous emulsions using castor oil and silicone oils offer stable drug delivery. These systems show potential for controlled release of lipophilic drugs like dehydroepiandrosterone (DHEA) and dexamethasone.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Anhydrous emulsions are explored for controlled drug delivery.
- Lipophilic drugs require specialized vehicles for effective administration.
Purpose of the Study:
- To formulate and characterize novel anhydrous emulsions for controlled drug delivery.
- To evaluate the stability and drug release profiles of these emulsions.
Main Methods:
- Formulation of anhydrous emulsions using castor oil (disperse phase) and silicone oils (continuous phase).
- Screening of silicone surfactants for emulsion stabilization.
- Characterization of emulsion stability, globule size, and interfacial tension.
- In vitro drug release studies using 3H-dehydroepiandrosterone (DHEA) and 3H-dexamethasone.
Main Results:
- Silicone surfactants (cyclomethicone/dimethicone copolyols) stabilized the emulsions.
- Specific silicone surfactants effectively reduced interfacial tension and ensured emulsion stability.
- Stable emulsions with minimal globule growth (2-6 microm) were achieved.
- Slow, controlled release of DHEA and dexamethasone over 48 hours was observed.
Conclusions:
- Novel anhydrous emulsions demonstrate stability and potential as depot vehicles for lipophilic drugs.
- Silicone surfactants are crucial for stabilizing these oil-in-oil systems.
- The developed emulsions facilitate controlled release, showing promise for drug delivery applications.