Related Experiment Video
Updated: Aug 17, 2026
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
Smoking, apolipoprotein E genotype, and early onset of coronary heart disease
Michael Loew1, Michael M Hoffmann, Harry Hahmann
1Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany. loew@dzfa.uni-heidelberg.de
Background:
We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD).
Design And Methods:
Smoking behaviour and ApoE genotype of 904 patients with CHD aged 30-70 years were assessed with respect to age at onset of CHD.
Results:
The adjusted odds ratio for early onset of CHD (< or =55 years) was 1.86 (95% confidence interval, 1.31-2.62) for smokers compared to non-smokers. The ApoE genotype had no significant influence and there was no significant interaction between ApoE genotype and smoking.
Conclusion:
We found smoking but not ApoE genotype to be an independent risk factor for early onset of CHD.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:26Atherosclerosis III: Management
01:30Atherosclerosis I: Introduction
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
01:29Alzheimer Disease l: Introduction
01:26Coronary Artery Disease II: Pathophysiology