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Updated: Aug 17, 2026
Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model
Maki Murakami1, Hiroyoshi Ota, Atsushi Sugiyama
1Department of Gastroenterological Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Background:
Rice extract has been shown to protect gastric mucosa from stress-induced damage. In this study, the antibiotic effect and the anti-inflammatory effect of orally administered aqueous rice extract on Helicobacter pylori infection and H. pylori-induced gastritis, respectively, in Mongolian gerbils were investigated.
Methods:
Fifty specific-pathogen-free male Mongolian gerbils, seven weeks old, were divided into four groups: uninfected, untreated animals (group A); uninfected, rice extract-treated animals (group B); H. pylori-infected, untreated animals (group C); and H. pylori-infected, rice extract-treated animals (group D). Group C and D animals were killed 12 weeks after H. pylori infection (i.e., at 19 weeks of age) and group A and B animals were also killed at age 19 weeks. The stomachs were removed for histopathological examination with hematoxylin-and-eosin staining and anti-5'-bromo-2'-deoxyuridine (BrdU) immunostaining, and to determine the bacterial burden. Serum anti-H. pylori antibody titers were also tested.
Results:
In groups A and B, the gastric mucosa showed no inflammatory cell infiltration and a few BrdU-reactive cells. Group C animals developed marked chronic active gastritis in the gastric mucosa, and BrdU-labeled cells in the gastric mucosa markedly increased in number. In group D animals, a significant reduction occurred in the degree of neutrophilic polymorphonuclear cell infiltration into the gastric mucosa, in the BrdU-labeling indices of gastric epithelial cells, and in anti-H. pylori antibody titers in the serum (P < 0.01), compared with although H. pylori was not completely eradicated.
Conclusions:
The rice extract was effective in suppressing inflammation and epithelial cell proliferation in the gastric mucosa in H. pylori-infected Mongolian gerbils. The rice extract has potential to exhibit a protective effect on H. pylori-related gastric mucosal diseases.
Insights
Rice extract reduced inflammation and cell proliferation in gerbils infected with Helicobacter pylori. This suggests rice extract may protect against H. pylori-related gastric diseases.
Area of Science:
- Gastroenterology
- Microbiology
- Pharmacology
Background:
- Rice extract demonstrates protective effects against stress-induced gastric mucosal damage.
- Investigated the antibiotic and anti-inflammatory properties of aqueous rice extract in Helicobacter pylori infection.
Purpose of the Study:
- To evaluate the efficacy of orally administered rice extract in a Mongolian gerbil model of H. pylori infection.
- To assess the impact of rice extract on H. pylori-induced gastritis and bacterial burden.
Main Methods:
- Fifty specific-pathogen-free male Mongolian gerbils were divided into four groups: uninfected/untreated, uninfected/rice extract-treated, H. pylori-infected/untreated, and H. pylori-infected/rice extract-treated.
- Stomachs were examined histopathologically (H&E staining, BrdU immunostaining) and bacterial burden determined.
- Serum anti-H. pylori antibody titers were measured.
Main Results:
- H. pylori-infected gerbils (untreated) developed chronic active gastritis and increased gastric epithelial cell proliferation (BrdU labeling).
- Rice extract treatment significantly reduced neutrophilic infiltration, epithelial cell proliferation, and serum anti-H. pylori antibody titers (P < 0.01).
- H. pylori was not completely eradicated by the rice extract.
Conclusions:
- Aqueous rice extract effectively suppressed inflammation and epithelial cell proliferation in H. pylori-infected gerbils.
- Rice extract shows potential for protecting against H. pylori-related gastric mucosal diseases.
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