Related Experiment Video

Updated: Aug 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Dermatofibrosarcoma protuberans occuring in a child

D Peschos1, P Dallas, A Doulis

  • 1Dept. of Forensic Medicine, Medical School, University of Ioannina, Greece.

Journal of Experimental & Clinical Cancer Research : CR
|June 10, 2005
PubMed

Insights

Dermatofibrosarcoma protuberans (DFSP) is rare in children, making diagnosis challenging. This case highlights the importance of considering DFSP in pediatric patients with persistent skin lesions.

Area of Science:

  • Pediatric Oncology
  • Dermatopathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare skin neoplasm.
  • DFSP typically affects adults but can occur in pediatric patients.
  • Diagnosis in children is challenging due to rarity and varied presentation.

Observation:

  • An 11-year-old boy presented with a 2-year history of a gradually growing lesion on his right shoulder.
  • The lesion initially appeared as a red-brown plaque and evolved into a nodule.
  • The lesion was slightly raised and non-tender.

Findings:

  • Histological and immunohistochemical examination confirmed the diagnosis of DFSP.
  • DFSP is characterized as a borderline or intermediate malignancy.
  • It has a high recurrence rate but low metastatic potential.

Implications:

  • This case underscores the diagnostic difficulties of pediatric DFSP.
  • Early recognition and accurate diagnosis are crucial for appropriate management.
  • Understanding DFSP behavior in children is vital for long-term patient outcomes.

More Related Videos

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...