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Synchronous colon and gastric advanced carcinomas
A Giuliani1, M Demoro, M Corona
1Dept. of Surgery Pietro Valdoni La Sapienza University, Rome, Italy. andrea.giuliani@uniroma1.it
Journal of Experimental & Clinical Cancer Research : CR
|June 10, 2005
Summary
This case study reports an unusual instance of synchronous colon and gastric cancer in a young woman. Surgical treatment was successful, with the patient remaining disease-free two years post-operation.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Synchronous primary malignancies in the colon and stomach are rare, particularly in younger patients.
- Early diagnosis of gastrointestinal cancers is crucial for effective management and improved patient outcomes.
Observation:
- A 36-year-old female presented with symptoms suggestive of colon cancer, including abdominal pain and rectal bleeding.
- Endoscopy revealed a stenosing right colon tumor with multiple polyps; CT scan confirmed the colonic lesion.
- Laparotomy unexpectedly identified an incidental antral gastric cancer alongside the colon carcinoma.
Findings:
- Histological analysis confirmed poorly differentiated gastric adenocarcinoma (Stage IB) and moderately differentiated colon adenocarcinoma (Stage III, Dukes C).
- Both tumors exhibited low expression of p53 and c-erb2 oncoproteins, with no identified APC or MMR gene mutations.
- The patient underwent en bloc hemigastrectomy and subtotal colectomy, with successful restoration of digestive continuity.
Implications:
- This case highlights the importance of thorough investigation in patients presenting with gastrointestinal symptoms, even at a young age.
- Synchronous gastric and colon cancers require a comprehensive surgical approach and detailed pathological evaluation.
- Long-term follow-up is essential to monitor for recurrence in patients treated for advanced synchronous gastrointestinal malignancies.