Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Syllogistic reasoning performance in MDMA (Ecstasy) users.

Catharine Montgomery1, John E Fisk, Russell Newcombe

  • 1School of Psychology, Liverpool John Moores University, UK.

Experimental and Clinical Psychopharmacology
|June 10, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of Alcohol Use Disorder Pharmacotherapies by Sex: Systematic Review and Meta-Analysis.

Drug and alcohol review·2026
Same author

The Socioeconomic Impact of Long-Acting Injectable Buprenorphine.

ClinicoEconomics and outcomes research : CEOR·2026
Same author

Everyday discrimination in individuals seeking treatment/receiving support for substance use and caregivers.

The International journal on drug policy·2026
Same author

The stigma of alcohol use during pregnancy: Exploring the impact of alcohol strength and social context on public perceptions.

PloS one·2026
Same author

A thematic analysis of flu vaccine hesitance in ethnically minoritised communities in Liverpool.

PloS one·2025
Same author

Investigating outcomes in a substance use treatment provider: a cross-sectional comparison of long-acting injectable buprenorphine and oral medication for opioid use disorder.

BMJ open·2025

Recreational MDMA (3,4-methylenedioxymethamphetamine; Ecstasy) users show impaired syllogistic reasoning. These deficits appear linked to working memory and executive functioning, suggesting cognitive impacts of MDMA use.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychopharmacology

Background:

  • Recreational MDMA (Ecstasy) use is associated with working memory and executive function deficits.
  • Working memory and executive functions are critical for complex cognitive tasks like syllogistic reasoning.

Purpose of the Study:

  • To investigate the impact of recreational MDMA use on syllogistic reasoning performance.
  • To determine if working memory and executive functioning mediate the relationship between MDMA use and reasoning abilities.

Main Methods:

  • Compared syllogistic reasoning, working memory, and executive functioning in 22 recreational MDMA users and 26 nonuser controls.
  • Controlled for potential confounding factors, including the use of other drugs.

Related Experiment Videos

Main Results:

  • MDMA users exhibited significant impairments in syllogistic reasoning, even after controlling for other drug use.
  • The significant effect of MDMA on reasoning disappeared when accounting for differences in working memory span.
  • Executive functioning deficits were implicated as a potential mechanism underlying impaired reasoning in MDMA users.

Conclusions:

  • Recreational MDMA use is associated with deficits in syllogistic reasoning.
  • Working memory and executive functioning appear to be key cognitive domains affected by MDMA, mediating reasoning impairments.