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Related Experiment Videos

Fetal and perinatal infections. A consecutive study.

H Rudbeck Røge1, U Henriques

  • 1Aarhus University Hospital, Kommunehospitalet, Denmark.

Pathology, Research and Practice
|February 1, 1992
PubMed
Summary

Infection is common in second-trimester abortions, stillbirths, and perinatal deaths, often without maternal symptoms. Early detection and prompt sample handling are crucial for accurate diagnosis.

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Area of Science:

  • Perinatal Medicine
  • Infectious Diseases
  • Pathology

Background:

  • Infection is a significant factor in adverse pregnancy outcomes.
  • Understanding the incidence and causes of infection in late pregnancy loss is crucial for improving maternal and infant health.

Purpose of the Study:

  • To determine the incidence of infection in second-trimester abortions, stillbirths, and perinatal deaths.
  • To assess correlations between infection and clinical parameters.
  • To evaluate the diagnostic value of placental and fetal cultures.

Main Methods:

  • Histological and microbiological examination of 118 cases of second-trimester abortions, stillbirths, and perinatal deaths.
  • Correlation analysis with clinical data, including vaginal bleeding, membrane status, and labor type.

Main Results:

  • Overall infection rate was 39.4%, highest in second-trimester abortions (58.2%).
  • Infection was the leading cause of death in 45.5% of cases, often without maternal signs.
  • Significant correlations found between infection and vaginal bleeding, prolonged membrane rupture (>24 hours), and spontaneous labor.

Conclusions:

  • Infection is a major contributor to late pregnancy loss, frequently occurring subclinically.
  • Timely microbiological sampling is essential for accurate diagnosis.
  • Clinical factors like vaginal bleeding and prolonged ruptured membranes are associated with increased infection risk.

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