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Related Experiment Videos

Bladder-wall and pelvic-plexus stimulation with model microstimulators: Preliminary observations.

James S Walter1, Mary Pat Fitzgerald, John S Wheeler

  • 1Research Service, Department of Veterans Affairs (VA) Edward Hines Jr. Hospital, Hines, IL 60141, USA. James.Walter@med.va.gov

Journal of Rehabilitation Research and Development
|June 10, 2005
PubMed
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Electrical stimulation of the bladder neck (pelvic plexus) may improve bladder emptying in cases of severe urinary retention. This preliminary study in cats suggests pelvic plexus stimulation offers a better response with fewer side effects than bladder wall stimulation.

Area of Science:

  • Urology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Severe urinary retention is a challenging condition, often occurring post-pelvic surgery or due to other medical issues.
  • Electrical stimulation of the bladder is being explored as a management strategy for urinary retention.
  • Previous methods lacked optimal efficacy and were associated with side effects like discomfort.

Purpose of the Study:

  • To investigate the hypothesis that pelvic plexus (bladder-neck) stimulation is more effective for micturition response than bladder-wall stimulation.
  • To assess and compare the side effects, such as animal movement and discomfort, associated with different stimulation locations.
  • To evaluate the efficacy of novel microstimulators in managing urinary retention.

Main Methods:

Related Experiment Videos

  • Preliminary investigations were conducted on four female cats using survival surgery.
  • Model microstimulators were employed to mimic commercial devices.
  • Studies involved both conscious and anesthetized animals over a 1-month period, varying stimulation parameters and electrode placements.

    • Main Results:

    • Two cats responded to low-current stimulation with bladder contractions and voiding.
    • Higher currents under anesthesia increased bladder contractions in two of three cats.
    • Pelvic-plexus stimulation demonstrated greater micturition responses compared to direct bladder-wall stimulation in two instances.

    Conclusions:

    • Stimulation at the pelvic plexus (bladder neck) may yield superior micturition responses compared to stimulation higher on the bladder wall.
    • These preliminary findings suggest potential for pelvic plexus stimulation in treating urinary retention.
    • Further research with commercially available microstimulators is warranted for clinical application.