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One-year angiotensin-converting enzyme inhibition plus mycophenolate mofetil immunosuppression in the course of early

Antonio Dal Canton1, Amore Amore, Giancarlo Barbano

  • 1Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo and University of Pavia, Pavia. dalcanton@mbox.medit.it

Journal of Nephrology
|June 10, 2005
PubMed

Angiotensin converting-enzyme inhibition (ACEI) is a widely accepted treatment during established renal diseases and beneficial effects have also been reported in IgA nephropathy (IgAN). Immunosuppression with myco-phenolate mofetil (MMF) has recently been introduced in the treatment of immune-mediated renal diseases showing promising results. Preliminary clinical reports are also suggestive that MMF is effective in severe forms of IgAN. We propose a randomised prospective trial aimed to compare long-term renal survival of early IgAN in the course of ACEI therapy with or without MMF immunosuppression.

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