Brief repetitive balloon occlusions enhance reperfusion during percutaneous coronary intervention for acute...

The objective of this study was to determine whether acutely ischemic myocardium may be conditioned during percutaneous coronary intervention for acute myocardial infarction. Ischemic preconditioning is a powerful cardioprotective mechanism that limits infarct size in animal investigations and ischemic sequelae during percutaneous coronary intervention in man. However, the conditioning stimulus in all these studies has been applied prior to the defining episode of ischemia. Seventeen patients undergoing percutaneous coronary intervention for acute myocardial infarction were randomly assigned to a standard ischemic preconditioning protocol (n = 10) or a usual-care control group (n =7). ST segment shift response and Doppler-derived distal coronary velocity data were compared. Despite similar degrees of baseline ST segment elevation, the magnitude of final ST segment elevation in the conditioning group was less than that in controls at the protocol conclusion (conditioning, 1.60 +/- 0.8 mV; control, 4.0 +/- 0.5 mV; P < 0.001). The rate of ST segment resolution was greater in the conditioning group (conditioning, 0.28 +/- 0.1 mV/min; control, 0.12 +/- 0.1 mV/min; P = 0.02). Distal coronary velocimetry indicated significant improvement in coronary flow velocity reserve in the conditioning group at the protocol conclusion (conditioning, 1.8 +/- 0.2; control, 1.4 +/- 0.1; P < 0.008). Brief periods of occlusion and reperfusion during percutaneous intervention for acute myocardial infarction mitigate the extent of ischemic injury and improve distal myocardial perfusion. Such ischemic conditioning represents a potentially useful adjunct to strategies for enhancing reperfusion during acute myocardial infarction.