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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Prospective study among cutaneous leishmaniasis cases in Tripoli Central Hospital, Tripoli, Libya

A A El Buni1, H Edwebi, A L Ben Darif

  • 1Medical Microbiology and Parasitology Department, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya.

Archives De L'Institut Pasteur De Tunis
|January 1, 1997
PubMed

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...