Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endothelial function and ischemic heart disease].

István Préda1, Jusztina Bencze, Katarina Vargova

  • 1Országos Gyógyintézeti Központ.

Orvosi Hetilap
|June 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurring Bleeding Events Requiring Red Blood Cell Transfusion After Left Atrial Appendage Closure Are Associated with Increased Mortality.

Journal of clinical medicine·2026
Same author

Cardiac Index by Transthoracic Echocardiography (CITE) study.

PloS one·2018
Same author

[Novel mechanisms in the initiation and maintenance of atrial fibrillation: tailored individual treatment].

Orvosi hetilap·2018
Same author

Alternative complement pathway activation during invasive coronary procedures in acute myocardial infarction and stable angina pectoris.

Clinica chimica acta; international journal of clinical chemistry·2016
Same author

A Simple Numerical Body Surface Mapping Parameter Signifies Successful Percutaneous Coronary Artery Intervention.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·2015
Same author

Five-year outcomes of staged percutaneous coronary intervention in the SYNTAX study.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2015

Endothelial dysfunction, triggered by cardiovascular risk factors, initiates atherosclerosis. Novel methods like laser Doppler flowmetry and circulating endothelial cell evaluation are advancing the detection of this critical early stage in heart disease.

Area of Science:

  • Cardiovascular Science
  • Pathophysiology
  • Medical Diagnostics

Background:

  • The 'response-to-injury' hypothesis posits endothelial dysfunction as the initial step in atherosclerosis and ischemic heart disease.
  • Cardiovascular risk factors can trigger endothelial dysfunction, initiating a slow inflammatory process.
  • This process involves low-density lipoprotein oxidation, immune activation, and plaque development, potentially leading to atherothrombotic lesions.

Purpose of the Study:

  • To review the role of endothelial dysfunction in atherosclerosis.
  • To highlight emerging laboratory and clinical methods for detecting endothelial dysfunction.
  • To discuss novel diagnostic approaches in ischemic heart disease.

Main Methods:

  • Flow-mediated dilation (FMD) is a recognized method for assessing endothelial function.

Related Experiment Videos

  • Laser Doppler flowmetry is an emerging technique for routine clinical application.
  • Coronarographic evaluation of intravascular flow velocity and isolation of circulating endothelial cells are under clinical investigation.

    • Main Results:

    • Endothelial dysfunction is a key early event in the development of atherosclerotic plaque.
    • Advanced diagnostic tools are being developed to detect and evaluate endothelial dysfunction.
    • Clinical studies are exploring novel markers and imaging techniques for ischemic heart disease.

    Conclusions:

    • Endothelial dysfunction is central to the pathogenesis of atherosclerosis and ischemic heart disease.
    • Novel diagnostic methods show promise for earlier and more accurate detection of cardiovascular disease.
    • Further research into these methods could improve patient outcomes in cardiology.