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Disseminated liposarcoma in a dog.
Fun-In Wang1, Sao-Ling Liang, Hock-Liew Eng
1Department of Veterinary Medicine, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei, 106 Taiwan, ROC.
Summary
A rare canine bone tumor originating in the L6 vertebrae caused hindlimb weakness and spread to ribs, heart, lungs, spleen, and kidneys. This osteolytic tumor exhibited varied cell types and stained positive for vimentin and S-100.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Skeletal Tumors
Background:
- A 9-year-old female Mongrel dog presented with hindlimb weakness and pain.
- Radiography revealed a lytic lesion in the lumbosacral region, extending to the ilium.
Observation:
- A large, firm mass was found originating from the L6 vertebrae, invading the sacrum, ilium, and acetabulum.
- Metastatic tumor nodules were identified in the ribs, heart, lungs, spleen, and kidneys.
Findings:
- Histopathology showed osteolysis with reactive bone formation and multinucleated osteoclasts.
- Neoplastic cells were pleomorphic, including small basophilic round cells, polygonal cells, and adipocyte-like cells.
- Immunohistochemistry revealed tumor cells positive for vimentin and S-100, and negative for other markers.
Implications:
- The tumor likely originated in the bone marrow of L6 and metastasized widely.
- This case highlights a rare, aggressive bone tumor in dogs with extraskeletal involvement.
- Further research into canine bone tumor biology and treatment is warranted.