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Updated: Aug 10, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Cromer-related blood group antigens and the glycosyl phosphatidylinositol-linked protein, decay-accelerating factor

M E Reid1

  • 1International Blood Group Reference Laboratory, South Western Regional Transfusion Centre, Southmead Road, Bristol, BS10 5ND, UK.

Immunohematology
|January 1, 1990
PubMed

Insights

Cromer-related blood group antigens, found on decay-accelerating factor (DAF), are absent in individuals with the Inab phenotype and paroxysmal nocturnal hemoglobinuria (PNH) III red blood cells.

Area of Science:

  • Hematology
  • Immunology
  • Biochemistry

Background:

  • Cromer-related blood group antigens are associated with decay-accelerating factor (DAF), a complement regulatory glycoprotein.
  • DAF plays a crucial role in protecting red blood cells from complement-mediated damage.

Purpose of the Study:

  • To investigate the presence of Cromer-related antigens on red blood cells in individuals with specific hematological conditions.
  • To understand the relationship between DAF expression and the Inab phenotype and paroxysmal nocturnal hemoglobinuria (PNH).

Main Methods:

  • Analysis of red blood cell surface antigen expression.
  • Phenotypic characterization of individuals with Inab and PNH III.

Main Results:

  • DAF is undetectable on red cells from individuals with the Inab phenotype, suggesting an inherited condition.
  • DAF is also absent from a subpopulation of red cells (PNH III) in patients with paroxysmal nocturnal hemoglobinuria (PNH), an acquired disorder.
  • Both Inab and PNH III red cells lack all identified Cromer-related antigens.

Conclusions:

  • The absence of Cromer-related antigens in Inab and PNH III red cells highlights the importance of DAF in expressing these antigens.
  • These findings contribute to understanding the genetic and acquired defects affecting red blood cell surface glycoproteins and their associated blood group antigens.

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