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Updated: Aug 17, 2026

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
Published on: October 6, 2023
Close encounters of the monoamine kind: immune cells betray their nervous disposition
Elizabeth J Meredith1, Anita Chamba, Michelle J Holder
1MRC Centre for Immune Regulation, The Medical School, University of Vincent Drive, Birmingham B15 2TT, UK.
Abstract:
Here we review the evidence for immune cells expressing multiple components of the serotonergic and dopaminergic systems that are more commonly associated with the central nervous system (CNS). We discuss where and how peripheral encounters with these biogenic monoamines occur and posit reasons as to why the immune system would wish to deploy these pathways. A full taxonomy of serotonergic and dopaminergic constituents and their workings in component cells of the immune system should facilitate the formulation of novel therapeutic approaches in diseases characterized by immune dysfunction and potentially provide a range of surrogate peripheral markers for registering and monitoring disturbances within the CNS.
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