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Endurance training changes central and peripheral responses to physostigmine.
1Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield 62794-9230.
Pharmacology, Biochemistry, and Behavior
|April 1, 1992
Summary
Acute exercise and endurance training have opposite effects on physostigmine's interaction with cholinesterase (ChE) enzymes in rat tissues. Exercise type significantly alters the rate of decarbamylation, impacting drug efficacy.
Area of Science:
- Pharmacology
- Exercise Physiology
- Biochemistry
Background:
- Physostigmine (Phy) is a reversible cholinesterase (ChE) inhibitor.
- Exercise can influence drug pharmacodynamics.
- The effect of exercise type on Phy-ChE interaction is not well understood.
Purpose of the Study:
- To investigate how acute exercise (AE) and endurance training (ET) affect the pharmacodynamics of physostigmine.
- To determine the impact of AE and ET on the rate of decarbamylation (Kd) of ChE in rat brain and various tissues.
Main Methods:
- Rats were subjected to acute exercise or endurance training protocols.
- Physostigmine was administered post-exercise.
- Cholinesterase activity and the rate of decarbamylation (Kd) were measured in brain, red blood cells (RBC), heart, diaphragm, and muscle tissues.
Main Results:
- AE + Phy increased ChE activity and Kd in brain and diaphragm, but decreased Kd in muscle.
- ET + Phy decreased ChE activity and Kd in brain, heart, and diaphragm, with no effect on muscle Kd.
- RBC-ChE showed a slight Kd increase with AE + Phy.
Conclusions:
- Acute exercise and endurance training exert opposing effects on the pharmacodynamics of physostigmine.
- Exercise-induced alterations in ChE decarbamylation rates can significantly modify the interaction of physostigmine with ChE in different tissues.