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Updated: Aug 17, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
[Correlation between expression of matrix metalloproteinase-2 and angiogenesis in esophageal carcinoma]
Jie-ru Li1, Feng-ying Qi, Li Li
1Department of Pathology, Heibei Medical Collage, Shijiazhuang 050017, China.
Objective:
To study expression of MMP-2 in relation to microvessel density (MVD) in esophageal carcinoma.
Methods:
Forty-eight specimens of esophageal carcinoma (Ec) and 17 specimens of grade II + III epithelial dysplasia (Dy) close to the tumor and 12 specimens of normal tissue (Nt) along the incisional margin were examined by S-P immunohistochemical staining with anti-MMP-2 monoclonal antibody. An anti-CD34 monoclonal antibody was used to show MVD.
Results:
MMP-2 expression in Ec was remarkably higher than that in Dy, which was higher than that in Nt. MMP-2 expression in Ec and Dy was significantly correlated with MVD in the tumor and nearby tissue. MMP-2 expression and MVD in Ec significantly associated with lymph node metastasis.
Conclusion:
Expression of MMP-2 plays an important role in angiogenesis and lymph node metastasis of esophageal cancer.
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