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RGD mounted on an L-proline scaffold
Eric Enholm1, Ashwin Bharadwaj
1Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. enholm@chem.ufl.edu
Bioorganic & Medicinal Chemistry Letters
|June 11, 2005
Abstract:
The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product.
