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Related Experiment Video

Updated: Jul 20, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

Latest advances in understanding preeclampsia.

Christopher W Redman¹, Ian L Sargent

¹Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. christopher.redman@obs-gyn.ox.ac.uk

Science (New York, N.Y.)

|June 11, 2005

Summary

Preeclampsia, a placental disorder, involves maternal immune recognition of the fetus and placental factors. Understanding these factors is key to addressing maternal and fetal complications in this common pregnancy condition.

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The Immediate Partial Removal of Cumulus-Oocyte Complexes: A Refined Approach for Rapid Observation of In Vitro Fertilization

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Published on: October 18, 2024

Area of Science:

Obstetrics and Gynecology
Immunology
Maternal-Fetal Medicine

Background:

Preeclampsia is a common pregnancy disorder originating in the placenta.
It can cause significant maternal and fetal health problems, potentially threatening survival.
The exact causes and mechanisms of preeclampsia are still under investigation.

Purpose of the Study:

To summarize recent research on the causes of preeclampsia.
To highlight new findings regarding maternal immune recognition of the fetus in preeclampsia.
To improve understanding of circulating factors derived from the placenta in preeclampsia.

Main Methods:

Review of recent scientific literature on preeclampsia.
Focus on studies investigating placental origins and maternal immune responses.
Analysis of research on circulating factors associated with the condition.

Main Results:

Recent work reveals a novel mode of maternal immune recognition of the fetus.
Circulating factors originating from the placenta are better understood.
These findings offer new insights into the pathophysiology of preeclampsia.

Conclusions:

New understanding of maternal immune recognition is relevant to preeclampsia.
Improved knowledge of placental factors contributes to understanding the clinical syndrome.
Further research into these areas may lead to better management and treatment of preeclampsia.