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Related Experiment Videos

Association between impaired insulin sensitivity and stroke.

Dawn M Bravata1, Carolyn K Wells, Walter N Kernan

  • 1Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA. Dawn.Bravata@yale.edu

Neuroepidemiology
|June 11, 2005
PubMed
Summary

Insulin resistance, measured by HOMA, is independently linked to stroke risk in adults over 40, even when accounting for blood sugar control.

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Area of Science:

  • Cardiovascular Science
  • Metabolic Disease Research
  • Epidemiology

Background:

  • Prior studies suggest a link between insulin resistance and stroke.
  • The persistence of this association after accounting for stroke risk factors requires further investigation.

Purpose of the Study:

  • To determine if insulin resistance is independently associated with stroke.
  • To assess the impact of glycemic control on this association.

Main Methods:

  • Utilized data from the Third National Health and Nutrition Survey (NHANES III) (1988-1994).
  • Assessed insulin sensitivity using the Homeostasis Model Assessment (HOMA) formula.
  • Employed multivariable logistic regression, adjusting for key stroke risk factors including HbA1c.

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Main Results:

  • A history of stroke was reported by 4% of the 3,844 participants.
  • Individuals with stroke exhibited significantly lower insulin sensitivity (higher HOMA values).
  • HOMA was independently associated with stroke (OR 1.06, 95% CI: 1.01-1.12), even after adjusting for HbA1c and other risk factors.

Conclusions:

  • Impaired insulin sensitivity is a significant independent predictor of stroke.
  • This association remains robust even when controlling for glycemic control (HbA1c).