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Related Experiment Videos

Spinal cord control of ejaculation.

Julien Allard1, William A Truitt, Kevin E McKenna

  • 1Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Cincinnati, OH 45267-0521, USA.

World Journal of Urology
|June 11, 2005
PubMed
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Researchers identified specific neurons in the lumbar spinal cord (LSt cells) that are crucial for controlling ejaculation. These LSt cells act as a key part of the spinal ejaculation generator, coordinating the reflex.

Area of Science:

  • Neuroscience
  • Reproductive Biology
  • Physiology

Background:

  • Ejaculation is a complex reflex controlled by a spinal ejaculation generator.
  • This generator integrates sensory input and coordinates motor output for emission and expulsion.
  • Neurons in the lumbosacral cord are known to be involved in these functions.

Purpose of the Study:

  • To characterize a specific population of spinothalamic neurons (LSt cells) in the lumbar spinal cord.
  • To determine the role of LSt cells within the spinal ejaculation generator.
  • To investigate the contribution of LSt cells to the control of ejaculation.

Main Methods:

  • Characterization of spinothalamic neurons (LSt cells) in male rats.
  • Tracing projections from LSt cells to autonomic nuclei and motoneurons.

Related Experiment Videos

  • Recording LSt cell activity during sexual behavior.
  • Lesioning LSt cells to assess the impact on ejaculatory function.

    • Main Results:

    • LSt cells were identified as integral components of the spinal ejaculation generator.
    • LSt cells project to relevant autonomic and motor pathways involved in ejaculation.
    • LSt cells are specifically activated during ejaculation, not other sexual behaviors.
    • Lesions of LSt cells completely abolished ejaculatory function.

    Conclusions:

    • LSt cells play a pivotal role in the control of ejaculation.
    • These neurons are essential for coordinating the neural pathways underlying the ejaculatory reflex.
    • The findings highlight LSt cells as a key target for understanding and potentially treating ejaculatory disorders.