Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endometrial cancer.

Andrew J Ryan1, Beatrice Susil, Thomas W Jobling

  • 1Department of Anatomical Pathology, Monash Medical Centre, Clayton, Victoria, Australia.

Cell and Tissue Research
|June 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic analysis of malignant ascites and its impact on ovarian cancer spheroids.

Clinical proteomics·2026
Same author

Enhanced expression of ADAMTS1 in ovarian carcinomas: loss of ADAMTS1 expression instigates cellular reprogramming of extracellular matrix ensuing altered plasticity, augmented migration and attenuated adhesion.

Journal of biomedical science·2026
Same author

Risk factors of ovarian cancer: a systematic review and meta-analysis of Mendelian randomiation studies.

Journal of public health (Oxford, England)·2026
Same author

Correction: Khan et al. Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. <i>Cancers</i> 2023, <i>15</i>, 4507.

Cancers·2026
Same author

Proteomic Studies That Predict Patients' Responses to High-Grade Serous Ovarian Cancer Treatments: A Systematic Review.

Journal of proteome research·2026
Same author

Toward Proteomic-Based Prediction of Ex Vivo Platinum Sensitivity in Ovarian Cancer Ascitic Cellular Aggregates: A Pilot Study.

Journal of proteome research·2025
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Endometrial cancer, a common gynecological malignancy, progresses through distinct molecular changes. Understanding these alterations in cellular pathways is key to developing effective treatment strategies for Type I and Type II endometrial cancers.

Area of Science:

  • Gynecological oncology
  • Molecular pathology
  • Cancer biology

Background:

  • Endometrial cancer is the most frequent gynecological malignancy globally.
  • Two main types exist: Type I (estrogen-dependent, endometrioid) and Type II (non-estrogen-dependent, serous/clear cell).
  • Cancer development is often a stepwise process involving accumulated molecular alterations.

Purpose of the Study:

  • To review current knowledge on molecular changes in endometrial cancer.
  • To present potential models for endometrial cancer progression.
  • To elucidate the transition from normal endometrium to carcinoma.

Main Methods:

  • Literature review of molecular alterations in endometrial cancer.
  • Analysis of clinico-pathological and molecular characteristics.

Related Experiment Videos

  • Synthesis of data to propose cancer progression models.

    • Main Results:

    • Endometrial cancer exhibits distinct molecular profiles for Type I and Type II.
    • Stepwise accumulation of genetic and epigenetic changes drives tumorigenesis.
    • Specific cellular regulatory pathways are commonly dysregulated.

    Conclusions:

    • Molecular understanding is crucial for classifying and treating endometrial cancer subtypes.
    • Further research into progression models can identify therapeutic targets.
    • Targeting dysregulated pathways may offer novel treatment strategies for endometrial cancer.