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[Heart failure in hypertension in the elderly]
1Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University.
Insights
Treating hypertension in elderly patients is crucial for preventing heart failure. Angiotensin-converting enzyme inhibitors, angiotensin-II receptor antagonists, and diuretics are recommended first-line therapies for blood pressure control.
Area of Science:
- Cardiology
- Geriatrics
- Pharmacology
Context:
- Heart failure, including systolic or diastolic ventricular dysfunction, is prevalent in elderly individuals with hypertension.
- Recent clinical trials and meta-analyses highlight the significance of managing hypertension in older adults to prevent chronic heart failure.
- Elderly hypertensive patients often present with comorbidities, target organ damage, and associated cardiovascular conditions.
Purpose:
- To emphasize the importance of treating hypertension in the elderly to prevent heart failure.
- To recommend first-line pharmacotherapies for blood pressure control in this demographic.
- To guide tailored therapeutic choices based on individual patient profiles.
Summary:
- The incidence and prevalence of heart failure are high in elderly hypertensive patients.
- Effective blood pressure management using angiotensin-converting enzyme inhibitors, angiotensin-II receptor antagonists, and low-dose diuretics is recommended as a primary strategy.
- Treatment selection should be individualized, considering additional risk factors and comorbidities, with beta-blockers, aldosterone blockers, and long-acting calcium antagonists being alternative or adjunctive options.
Impact:
- Improved prevention of chronic heart failure in the elderly population.
- Enhanced understanding of individualized pharmacotherapy for hypertension in older adults.
- Potential reduction in cardiovascular morbidity and mortality associated with hypertension and heart failure in the elderly.
Abstract:
Incidence and prevalence of heart failure, in the form of systolic or diastolic ventricular dysfunction, are particularly common in elderly patients with hypertension. The importance of treating hypertension in the elderly as a means of preventing chronic heart failure was emphasized by recent trials including meta-analysis. Fastidious blood pressure control by angiotensin-converting enzyme inhibitors and angiotensin-II receptor antagonists along with low-doses diuretics as first-line therapy is recommended. However, many elderly patients with hypertension have other risk factors, target organ damages and associated cardiovascular conditions, to which the choice of the first drug should be tailored. In such cases, beta blockers, aldosterone blockers and long-acting Ca antagonists are also recommended.
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