Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional MASP2 single nucleotide polymorphism plays no role in psoriasis.

C Stover1, S Barrett, N J Lynch

  • 1Department Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, UK. cms13@le.ac.uk

The British Journal of Dermatology
|June 14, 2005
PubMed
Summary

Genetic analysis of MASP-2 deficiency in psoriasis patients revealed no increased risk. This study found no association between MASP-2 gene variants and the development of psoriasis, suggesting it is not a significant risk factor.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A protocol for the development of a core outcome set for adults with depression.

Journal of clinical epidemiology·2025
Same author

Safety and Efficacy of Atezolizumab in Combination With nab-Paclitaxel in Patients With PD-L1 Positive Metastatic or Locally Advanced Triple-Negative Breast Cancer: A UK-Wide Cancer Centre Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Tracking positive emotions in the course of adult depression: A systematic scoping review of longitudinal studies.

Journal of affective disorders·2025
Same author

Bio-banding influences talent experts' ratings of psycho-social behaviours during 11 v 11 soccer match-play.

Journal of sports sciences·2025
Same author

Differences in physical and technical performance characteristics between 11v11 chronological and bio-banded soccer match-play format in male youth soccer.

Journal of science and medicine in sport·2025
Same author

Three-dimensional Reservoir Modelling and Quantitative Microbial Risk Assessment of Recreational Access to a Drinking Water Reservoir.

Environmental management·2025

Area of Science:

  • Genetics
  • Immunology
  • Dermatology

Background:

  • Psoriasis is a heritable skin condition with identified susceptibility loci.
  • The MASP-2 gene, crucial for complement activation, resides on chromosome 1p, a region linked to psoriasis susceptibility.

Purpose of the Study:

  • To investigate if MASP-2 deficiency (partial or total) represents a risk factor for psoriasis development.
  • Examining the role of MASP-2 gene variants in the pathogenesis of psoriasis.

Main Methods:

  • Screening of plaque psoriasis patients and their parents using restriction fragment length polymorphism (RFLP) analysis.
  • Genetic analysis to identify single nucleotide polymorphisms (SNPs) in the MASP-2 gene.

Main Results:

Related Experiment Videos

  • A specific single nucleotide polymorphism (SNP) was identified, causing an amino acid substitution and disrupting MASP-2 complex formation.
  • This identified mutant MASP-2 allele was not found to be associated with psoriasis in the studied cohort.
  • Allele frequencies for the mutant MASP-2 gene were similar in both psoriasis patients (0.0326) and unaffected individuals (0.0379).

    • Conclusions:

    • The mutant MASP-2 allele is not associated with an increased risk of developing psoriasis.
    • No preferential transmission of the mutant allele from parents to affected offspring was observed.
    • MASP-2 deficiency is unlikely to be a significant genetic risk factor for psoriasis.