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Related Experiment Videos

Extensive annular verrucous late secondary syphilis.

C C Pournaras1, I Masouye, P Piletta

  • 1Department of Dermatology, Geneva University Medical School, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland.

The British Journal of Dermatology
|June 14, 2005
PubMed
Summary

A man with alopecia universalis developed unusual skin lesions, diagnosed as extensive secondary syphilis. Early penicillin treatment led to rapid improvement, highlighting syphilis

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Syphilology

Background:

  • Late secondary syphilis is a systemic infection with diverse clinical manifestations.
  • Alopecia universalis, an autoimmune condition, may coexist with other dermatological disorders.

Observation:

  • A 38-year-old male with a history of alopecia universalis presented with a 6-month history of pruritic, verrucous annular skin lesions.
  • Lesions were distributed across the scalp, perioral, lumbar, perianal, and genital areas.

Findings:

  • The patient's clinical presentation, positive syphilis serology, and rapid response to penicillin confirmed extensive annular and verrucous late secondary syphilis.
  • This case highlights a rare and potentially misleading clinical presentation of late secondary syphilis.

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Implications:

  • Syphilis remains a relevant diagnosis in contemporary medical practice, even with atypical presentations.
  • Early recognition and treatment of secondary syphilis are crucial for favorable patient outcomes.
  • Clinicians should consider syphilis in the differential diagnosis of unusual dermatological conditions.