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Mycoplasma-enhanced priapism in mice
David Taylor-Robinson1, Patricia M Furr
1Division of Medicine A, Department of Medicine, Imperial College London, St Mary's Hospital, Paddington, London W2 1NY, UK. dtr@vache99.freeserve.co.uk
Abstract:
Priapism seen occasionally in mice used in various mycoplasmal studies over several years prompted further investigation. Of six strains of young adult male mice inoculated intravenously with Mycoplasma pulmonis, of murine origin, priapism was seen only in CBA mice, penile erections persisting in some for seven to 44 weeks. A few mice given broth medium without mycoplasmas also developed priapism, and mice given five mycoplasmal species, of human origin, developed the condition in a way similar to these controls. However, those given M. pulmonis developed priapism earlier and of longer duration than other mice, suggesting that it was an enhancing factor. The duration of the phenomenon is remarkable and, as yet, has no clear explanation.
Insights
Priapism, a persistent penile erection, was observed in mice during mycoplasma research. Mycoplasma pulmonis infection in CBA mice led to prolonged priapism, suggesting it enhances the condition.
Area of Science:
- Veterinary Medicine
- Microbiology
- Animal Models
Background:
- Priapism has been occasionally observed in mice during mycoplasma studies.
- The underlying causes and contributing factors for priapism in this context were not well understood.
Purpose of the Study:
- To investigate the occurrence and potential causes of priapism in mice undergoing mycoplasma research.
- To determine if specific Mycoplasma species or strains influence the development and duration of priapism.
Main Methods:
- Six strains of young adult male mice were intravenously inoculated with Mycoplasma pulmonis (murine origin).
- Control groups received sterile broth medium or Mycoplasma species of human origin.
- Observations focused on the incidence and duration of priapism in different experimental groups.
Main Results:
- Priapism was exclusively observed in CBA mice inoculated with Mycoplasma pulmonis, with durations ranging from 7 to 44 weeks.
- Control mice receiving broth medium or human-origin mycoplasmas also developed priapism, but less frequently and for shorter durations.
- Mycoplasma pulmonis appeared to be an enhancing factor for earlier onset and longer duration of priapism compared to other groups.
Conclusions:
- Mycoplasma pulmonis infection is associated with a significant and prolonged incidence of priapism in CBA mice.
- While not the sole cause, M. pulmonis appears to enhance the development and duration of priapism.
- The remarkable duration of priapism observed in this study warrants further investigation into its underlying mechanisms.
