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Genetically-induced deep venous thrombosis presenting as acute mastoiditis
Maurizio Barbara1, Calogera Consagra, Giuseppe Buongiorno
1Department of Otorhinolaryngology, Second Medical School, University La Sapienza, Rome, Italy. maurizio.barbara@uniroma1.it
The Journal of Laryngology and Otology
|June 14, 2005
Summary
Sigmoid sinus thrombosis, a rare complication of otitis media, can occur in children due to genetic thrombophilia. Early assessment of coagulation factors and surgical intervention are crucial for managing this life-threatening condition.
Area of Science:
- Neurology
- Otolaryngology
- Pediatrics
Background:
- Sigmoid sinus thrombosis (SST) is typically associated with acute or chronic otitis media and coalescent mastoiditis.
- Deep cerebral sinus thrombosis is an uncommon complication, particularly in the absence of coalescent mastoiditis.
Observation:
- A rare case of sigmoid sinus thrombosis in a young child with noncoalescent mastoiditis is presented.
- The patient had a genetic thrombophilic disorder, specifically the prothrombin G20210A allele mutation, identified as a predisposing factor.
Findings:
- The sigmoid sinus thrombosis showed regression only after surgical exploration and anticoagulant therapy.
- Genetic thrombophilia, such as the prothrombin G20210A mutation, can predispose individuals to unusual thrombotic events.
Implications:
- Early assessment of coagulation factors is recommended, especially in at-risk populations, to identify unusual causes of sigmoid sinus thrombosis.
- This case highlights the importance of considering genetic thrombophilia in pediatric patients with sinus thrombosis and otitis media.
- Prompt surgical intervention combined with anticoagulation may be necessary for managing severe cases of sigmoid sinus thrombosis.