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[Oral anticoagulants in clinical practice].

P Marko1, H Flückiger, S Christeller

  • 1Fakultäre Instanz für Allgemeinmedizin (FIAM), Universität Bern.

Schweizerische Medizinische Wochenschrift
|May 9, 1992
PubMed
Summary

Oral anticoagulation (OA) therapy in ambulatory settings proved effective and safe. This study demonstrates low complication rates, supporting its use in routine practice for eligible patients.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Oral anticoagulation (OA) use in ambulatory settings presents challenges regarding efficacy and safety.
  • Assessing OA performance is crucial for its continued application in outpatient care.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral anticoagulation in ambulatory practice.
  • To determine complication rates and therapeutic range adherence for OA in a real-world setting.

Main Methods:

  • A prospective study involving 538 patients across 24 ambulatory practices over one year.
  • Monitoring thromboplastin time, therapeutic range achievement, and adverse events.
  • Comparison of observed mortality rates with national averages.

Main Results:

  • 72% of thromboplastin times were within the target range, and 90.6% within the therapeutic range.
  • Bleeding complications occurred in 7.6% of patients (11.6/100 treatment years).
  • Low rates of OA interruption (2.6%), hospital admissions (2.3%), and no deaths attributed to OA complications were observed.

Conclusions:

  • Oral anticoagulation is highly effective in ambulatory practices.
  • The therapy demonstrates a low rate of complications, supporting its safe use in this setting.

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