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Interleukin-18 does not modulate the acute-phase response.

Rogier J L Stuyt1, Mihai G Netea, Ineke Verschueren

  • 1Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Journal of Endotoxin Research
|June 14, 2005
PubMed
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Recombinant Interleukin-18 (rIL-18), a pro-inflammatory cytokine, does not induce fever in rabbits. Studies also showed rIL-18 does not affect key markers of the acute-phase response in mice.

Area of Science:

  • Immunology
  • Cytokine Biology
  • Inflammation Research

Background:

  • Interleukin-18 (IL-18) is a pro-inflammatory cytokine within the IL-1 family.
  • IL-18 influences the production of other cytokines like IL-1, TNF, and IL-6, which are endogenous pyrogens.
  • Understanding the pyrogenic potential of IL-18 is crucial for its therapeutic applications.

Purpose of the Study:

  • To investigate the pyrogenic properties of recombinant IL-18 (rIL-18) in a rabbit fever model.
  • To assess the impact of rIL-18 on other components of the acute-phase response in mice.

Main Methods:

  • Intravenous injection of rIL-18 into rabbits to monitor for fever development.
  • Administration of rIL-18 to mice to evaluate changes in leukocytosis, lipoproteins, and corticosterone levels.

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Main Results:

  • rIL-18 administration did not induce a febrile response in rabbits.
  • rIL-18 did not cause leukocytosis in mice.
  • Circulating concentrations of lipoproteins and corticosterone remained unchanged in mice following rIL-18 exposure.

Conclusions:

  • Recombinant IL-18 does not possess pyrogenic activity in rabbits.
  • rIL-18 does not modulate key indicators of the acute-phase response in mice.
  • These findings suggest IL-18's role in fever induction and acute-phase modulation is limited.