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Elevated urinary dopamine in adults and children.

D Fraser Davidson1

  • 1Biochemistry Department, Crosshouse Hospital, Kilmarnock, Ayrshire KA2 0BE, UK. fraser.davidson@aaaht.scot.nhs.uk

Annals of Clinical Biochemistry
|June 14, 2005
PubMed
Summary

Elevated urinary dopamine in adults is often due to over-collection or medications, while in children, it can indicate neuroblastoma or other serious conditions. Further research is needed for unexplained findings.

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Area of Science:

  • Clinical Chemistry
  • Pediatric Oncology
  • Pharmacology

Background:

  • Limited understanding of elevated urinary dopamine can cause diagnostic confusion.
  • This study investigates associations with high urine dopamine levels in a large patient cohort.

Purpose of the Study:

  • To identify common causes of elevated urinary dopamine in adults and children.
  • To clarify the clinical significance of increased urine dopamine findings.

Main Methods:

  • Retrospective analysis of urine catecholamine and metabolite results from 5933 adults and 467 children.
  • High-performance liquid chromatography with electrochemical detection (HPLC-ECD) was used for analysis.
  • Investigation of clinical and laboratory data for patients with elevated dopamine.

Main Results:

  • In adults, elevated dopamine was linked to urine over-collection, drug effects (e.g., L-dopa, antidepressants), and clinical conditions (e.g., phaeochromocytoma, pregnancy).
  • In children, high urine dopamine was associated with neuroblastoma, Costello syndrome, leukemia, phaeochromocytoma, Menkes disease, and rhabdomyosarcoma.
  • Elevated dopamine was found in less than 3% of adult urine specimens.

Conclusions:

  • Elevated urinary dopamine in adults is most frequently associated with over-collection, drug effects, and neural crest tumors.
  • Neuroblastoma is the primary cause of elevated dopamine in children, though other conditions are noted.
  • Some cases of elevated dopamine require further investigation to determine their cause.

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