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Related Experiment Videos

Cripto-1: an oncofetal gene with many faces.

Caterina Bianco1, Luigi Strizzi, Nicola Normanno

  • 1Tumor Growth Factor Section, Mammary Biology & Tumorigenesis Laboratory Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Current Topics in Developmental Biology
|June 14, 2005
PubMed
Summary

Human Cripto-1 (CR-1) is vital for embryonic development and acts as an oncogene in adult tissues. Its overexpression drives mammary gland tumors and is found in many human carcinomas, highlighting its dual role.

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Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Molecular Oncology

Background:

  • Human Cripto-1 (CR-1), an epidermal growth factor (EGF)-CFC family member, is crucial for early vertebrate development, acting as a co-receptor for Nodal.
  • CR-1 is essential for mesoderm/endoderm formation and establishing embryonic axes.
  • In adult tissues, CR-1 expression is low but increases during pregnancy and lactation.

Purpose of the Study:

  • To investigate the dual role of CR-1 in embryogenesis and carcinogenesis.
  • To explore CR-1's function in mammary gland development and cancer progression.
  • To assess CR-1 expression in various human carcinomas.

Main Methods:

  • Studied CR-1's role in embryogenesis using Nodal co-receptor function.
  • Investigated CR-1's effects on mouse mammary epithelial cells in vitro (transformation, migration, invasion, EMT).

Related Experiment Videos

  • Utilized transgenic mouse models with CR-1 overexpression under MMTV promoter.
  • Analyzed CR-1 expression levels in human carcinoma tissues.

    • Main Results:

    • CR-1 overexpression in mouse mammary epithelial cells induced transformation, hyperplasia, and enhanced migration/invasion.
    • Transgenic mice overexpressing CR-1 developed mammary hyperplasias and papillary adenocarcinomas.
    • High CR-1 levels (50-80%) were observed in multiple human carcinomas (breast, cervix, colon, etc.).

    Conclusions:

    • EGF-CFC proteins, including CR-1, function as both embryonic pattern formation genes and oncogenes.
    • Aberrant CR-1 expression in adult tissues promotes cellular proliferation and transformation.
    • CR-1 is implicated in the etiology and progression of various cancers.