Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Attention-deficit/hyperactivity disorder: a selective overview.

Joseph Biederman1

  • 1Department of Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. jbiederman@partners.org

Biological Psychiatry
|June 14, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening for Attention-Deficit/Hyperactivity Disorder and Comorbidities in a Diverse, Urban Primary Care Setting.

Clinical pediatrics·2018
Same author

Does the course of manic symptoms in pediatric bipolar disorder impact the course of conduct disorder? Findings from four prospective datasets.

Journal of affective disorders·2018
Same author

Informativeness of Self-Reports of ADHD Symptoms in Monitoring Response to Stimulant Treatment in Clinically Referred Adults With ADHD.

Journal of attention disorders·2018
Same author

Attention and working memory deficits in a perinatal nicotine exposure mouse model.

PloS one·2018
Same author

High Risk for Severe Emotional Dysregulation in Psychiatrically Referred Youth with Autism Spectrum Disorder: A Controlled Study.

Journal of autism and developmental disorders·2018
Same author

The Mixed Opioid Receptor Antagonist Naltrexone Mitigates Stimulant-Induced Euphoria: A Double-Blind, Placebo-Controlled Trial of Naltrexone.

The Journal of clinical psychiatry·2018

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder affecting children and adults. Research suggests genetic and neurobiological factors contribute to ADHD, impacting cognitive function and treatment response.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a prevalent, multifactorial neurodevelopmental disorder with significant academic, vocational, and familial impacts.
  • Recognized in both children and adults, ADHD's clinical features are consistent across age groups, with persistence linked to family history, comorbidity, and adversity.

Purpose of the Study:

  • To review the current understanding of ADHD etiology, clinical correlates, and neurobiological underpinnings.
  • To explore risk factors, comorbidities, and the neurobiological basis of ADHD pathophysiology and treatment.

Main Methods:

  • Literature review synthesizing findings from epidemiological, genetic, family, neuroimaging, and clinical studies.
  • Analysis of risk factors including pregnancy complications, maternal smoking, and family environment.

Related Experiment Videos

Main Results:

  • ADHD exhibits strong familial aggregation, with significant genetic and neurobiological contributions.
  • Neuroimaging implicates fronto-subcortical pathway dysfunction and neurotransmitter imbalances (dopamine, norepinephrine).
  • Comorbidities include oppositional defiant disorder, conduct disorder, mood, and anxiety disorders.

Conclusions:

  • ADHD pathophysiology involves fronto-subcortical circuit dysfunction and altered dopaminergic/noradrenergic systems.
  • Pharmacological treatments targeting these neurotransmitter systems are effective in managing ADHD symptoms.
  • Understanding the neurobiological basis is crucial for effective ADHD management and treatment strategies.