Listening to the brain: microelectrode biosensors for neurochemicals

Chemical signalling underlies every function of the nervous system, from those of which we are unaware, for example, control of the heart, to higher cognitive functions, such as emotions, learning and memory. Neurotransmitters and neuromodulators mediate communication between neurons and between neurons and non-neural cells such as glia and muscle. In the past, the means for studying the production and release of these signalling agents directly has been limited in its temporal and spatial resolution relative to the dynamics of chemical signalling and the structures of interest in the brain. Now microelectrode biosensors are becoming available that give unprecedented spatial and temporal resolution, enabling, for the first time, direct measurement in real time of the chemical conversations between cells in the nervous system.