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The effectiveness of the mumps component of the MMR vaccine: a case control study

Richard Harling1, Joanne M White, Mary E Ramsay

  • 1HPA-CDSC, 61 Colindale Avenue, London NW9 5EQ, UK.

Vaccine
|June 14, 2005
PubMed

Insights

The MMR vaccine demonstrated 69% effectiveness against mumps during a London outbreak. Two doses of the measles, mumps, and rubella (MMR) vaccine were significantly more protective than a single dose.

Area of Science:

  • Epidemiology
  • Vaccinology
  • Public Health

Background:

  • Mumps outbreaks can occur even in vaccinated communities.
  • Assessing vaccine effectiveness in real-world scenarios is crucial for public health strategies.

Purpose of the Study:

  • To evaluate the effectiveness of the measles, mumps, and rubella (MMR) vaccine during a mumps outbreak.
  • To compare the effectiveness of single versus double doses of the MMR vaccine.

Main Methods:

  • A case-control study was conducted involving 161 mumps cases and 192 controls.
  • Vaccination history was compared between cases and controls.
  • Vaccine effectiveness was adjusted for age, sex, and general practice.

Main Results:

  • The observed effectiveness of at least one MMR vaccination was 69% (95% CI: 41-84%).
  • Two doses of the MMR vaccine showed higher effectiveness (88%; 95% CI: 62-96%) compared to a single dose (64%; 95% CI: 40-78%).
  • Observed effectiveness was lower than vaccine immunogenicity reported in clinical trials.

Conclusions:

  • The MMR vaccine provides significant protection against mumps, with two doses being optimal.
  • The findings support the current two-dose vaccination program for mumps control in the community.
  • Discrepancies between observational studies and clinical trials highlight the complexities of vaccine effectiveness assessment.

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