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Effects of nilvadipine on neuronal function in the ischemic cat brain
S Takakura1, Y Furuichi, H Satoh
1Department of Pharmacology, Fujisawa Pharmaceutical Co., Osaka, Japan.
Surgical Neurology
|April 1, 1992
Summary
vadipine, a calcium channel blocker, effectively protected neuronal function during and after focal cerebral ischemia in cats. This neuroprotective effect was measured by improved somatosensory evoked potentials and regional blood flow.
Area of Science:
- Neuroscience
- Pharmacology
- Cerebrovascular Research
Background:
- Focal cerebral ischemia poses a significant threat to neuronal function.
- Calcium entry blockers are investigated for their potential neuroprotective properties.
Purpose of the Study:
- To investigate the effect of nilvadipine, a dihydropyridine calcium entry blocker, on neuronal function during and after focal cerebral ischemia.
- To compare the efficacy of nilvadipine with nicardipine in a feline model.
Main Methods:
- A model of focal cerebral ischemia was induced in cats by occluding the middle cerebral artery (MCA) for 60 minutes.
- Drugs (nilvadipinevadipine or nicardipine) were administered intravenously 30 minutes before MCA occlusion.
- Neuronal function was assessed using somatosensory evoked potentials (SEPs).
- Regional cortical blood flow was measured in specific gyri.
Main Results:
- Nilvadipine treatment resulted in higher amplitudes of SEPs and greater residual relative regional cortical blood flow compared to control groups.
- SEPs showed rapid recovery after reperfusion in nilvadipine-treated cats.
- Nilvadipine administration before ischemia improved neuronal function both during and after the ischemic event.
Conclusions:
- Nilvadipine demonstrates significant efficacy in mitigating neuronal dysfunction associated with focal cerebral ischemia.
- The findings suggest nilvadipine possesses neuroprotective qualities beneficial in ischemic stroke scenarios.