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Updated: Aug 17, 2026
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Neomycin improves cationic lipid-mediated transfection of DNA in human cells
Sara Napoli1, Giuseppina M Carbone, Carlo V Catapano
1Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland (IOSI) Via Vela 6, 6500 Bellinzona, Switzerland.
Abstract:
Delivery of oligonucleotides has been a major impediment in the development of nucleic acid based drugs. In this report, we show that neomycin, an aminoglycoside antibiotic, when combined with a cationic lipid preparation such as DOTAP, enhances transfection efficiency of both reporter plasmids and oligonucleotides and results in a significant increase in transgene expression. The results described here open a new lead in ongoing efforts for oligonucleotide delivery.
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