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Updated: Jul 13, 2026
11:15
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Nasopharyngeal carcinoma
William I Wei1, Jonathan S T Sham
1Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China. hrmswwi@hkucc.hku.hk
Lancet (London, England)
|June 14, 2005
Summary
Early detection of nasopharyngeal carcinoma (NPC) is possible by detecting Epstein-Barr virus (EBV) antibodies and DNA. Improved treatments and screening offer hope for better outcomes in high-risk populations.
Area of Science:
- Oncology
- Virology
- Medical Diagnostics
Background:
- Nasopharyngeal carcinoma (NPC) incidence remains high in endemic areas.
- Early diagnosis relies on clinical acumen and histology, despite advances in imaging.
- Epstein-Barr virus (EBV) is a key factor in NPC development and detection.
Purpose of the Study:
- To highlight the role of EBV in NPC diagnosis and prognosis.
- To review current and potential therapeutic strategies for NPC.
- To emphasize the importance of early detection and screening in endemic regions.
Main Methods:
- Detection of EBV-encoded RNA in tumor cells.
- Measurement of antibodies against EBV in patient blood.
- Quantification of EBV DNA in blood for staging and prognosis.
- Review of treatment modalities including radiotherapy, chemotherapy, and surgical salvage.
Main Results:
- EBV presence is universal in NPC cells.
- Elevated EBV antibodies indicate early-stage disease.
- EBV DNA levels correlate with NPC stage and patient prognosis.
- Advanced treatments like intensity-modulated radiotherapy improve outcomes.
Conclusions:
- EBV detection is crucial for early nasopharyngeal carcinoma diagnosis.
- Combined treatments and improved detection methods enhance survival rates.
- Screening high-risk groups and exploring novel therapies like immunotherapy hold promise for future NPC management.
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