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Cranial computed tomographic observations in multi-infarct dementia. A controlled study.
P B Gorelick1, A Chatterjee, D Patel
1Department of Neurology (Stroke, Alzheimer, and Neuroepidemiology Services), Michael Reese Hospital and Medical Center, School of Public Health (Epidemiology and Biometry Program), University of Illinois, Chicago, Chicago, IL.
Stroke
|June 1, 1992
Summary
Multi-infarct dementia is associated with more brain infarcts and specific brain changes. Lower education, severe strokes, and left hemisphere infarcts predict multi-infarct dementia.
Area of Science:
- Neurology
- Neuroimaging
- Geriatrics
Background:
- Multi-infarct dementia (MID) is a significant cause of cognitive impairment.
- Understanding the neuroimaging determinants of MID is crucial for early diagnosis and intervention.
Purpose of the Study:
- To compare cranial computed tomography (CT) findings in patients with and without multi-infarct dementia.
- To identify potential neuroimaging and clinical predictors of multi-infarct dementia.
Main Methods:
- Cranial CT scans of 58 MID cases and 74 multi-infarct control subjects were analyzed.
- Infarct characteristics, brain volume loss, white matter lucency, and ventricular/sulcal enlargement were assessed.
- Patients were classified using Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition (DSM-III) criteria.
Main Results:
- MID cases exhibited more cerebral infarcts, particularly in the left hemisphere.
- Increased ventricular volume, enlarged sulci, and white matter lucencies were more prevalent in MID cases.
- Logistic regression identified education level, stroke severity, left cortical infarction, and left lateral ventricle enlargement as key predictors.
Conclusions:
- Education, stroke severity, and left hemisphere infarction are significant predictors of multi-infarct dementia.
- Neuroimaging findings like left cortical infarcts and ventricular enlargement contribute to predicting MID.