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Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells

Petra Hoffmann1, Tina J Boeld, Biserka Piseshka

  • 1Institute of Immunology, University Hospital Regensburg, University of Regensburg, Germany.

Microbes and Infection
|June 14, 2005
PubMed

Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation (BMT) caused by donor T cells. Immunosuppression mediated by CD4(+)CD25(+) regulatory T cells has been shown to ameliorate such pathogenic immune responses in animal models. Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT.

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