Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Vitamin D.

Adriana S Dusso¹, Alex J Brown, Eduardo Slatopolsky

¹Renal Division, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.

American Journal of Physiology. Renal Physiology

|June 14, 2005

Summary

The vitamin D system has complex actions beyond bone health, involving cell growth and immunity. New research reveals vitamin D (1,25(OH)(2)D) may have multiple receptors and ligands, impacting cell functions locally.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tailored Catalytic Microenvironments Enable Efficient Electrochemical Ammonia Production.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Current Controversies on Adequate Circulating Vitamin D Levels in CKD.

International journal of molecular sciences·2026

Same author

Non-Invasive Assessment of Vascular Damage Through Pulse Wave Velocity and Superb Microvascular Imaging in Pre-Dialysis Patients.

Biomedicines·2025

Same author

The effect of vitamin D supplementation on mental and functional health outcomes in African Americans with type 2 diabetes.

The Journal of steroid biochemistry and molecular biology·2025

Same author

Synthesis, Structure, and Properties of 2O-BaPtO<sub>3</sub>, a Phase Derived from Hexagonal Perovskite.

Inorganic chemistry·2024

Same author

A rotating white dwarf shows different compositions on its opposite faces.

Nature·2023

Area of Science:

Endocrinology and Molecular Biology
Calcium Homeostasis and Bone Metabolism
Cellular Signaling and Gene Regulation

Background:

The vitamin D endocrine system is crucial for calcium balance and bone health.
Recent research highlights vitamin D's broader roles in cell differentiation, growth inhibition, immunomodulation, and hormonal control.
Vitamin D is a prohormone converted to its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], which binds to the vitamin D receptor (VDR).

Purpose of the Study:

To review recent advancements in understanding vitamin D metabolism and its diverse biological actions.
To explore the complexities of vitamin D activation and VDR signaling pathways.
To discuss the implications of autocrine/paracrine vitamin D functions in target cells.

Main Methods:

Review of current literature on vitamin D metabolism and VDR actions.
Analysis of studies involving genetically modified mice lacking VDR and/or 1alpha-hydroxylase.
Examination of evidence for facilitated precursor uptake in vitamin D activation.

Main Results:

The final activation step of vitamin D involves facilitated precursor uptake and delivery to 1alpha-hydroxylase in renal proximal tubules.
Evidence suggests both 1,25(OH)(2)D(3)-dependent and -independent actions of the VDR, and VDR-dependent and -independent actions of 1,25(OH)(2)D(3).
The vitamin D system may involve more than one receptor and ligand.

Conclusions:

The vitamin D system's complexity extends beyond a single receptor-ligand interaction.
The presence of 1alpha-hydroxylase in target cells suggests autocrine/paracrine roles for 1,25(OH)(2)D(3) in cell proliferation and differentiation.
Local 1,25(OH)(2)D(3) production, dependent on precursor levels, may explain links between vitamin D deficiency and diseases like cancer and autoimmune disorders.

Related Experiment Videos